Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 3.132


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA7chr7_-_271626880.621.0e-02Click!
HOXB7chr17_-_440429240.601.5e-02Click!
HOXB6chr17_-_440373320.533.6e-02Click!
HOXA6chr7_-_271538920.449.1e-02Click!


Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_14076901 12.318 NFIB
nuclear factor I/B
chr7_-_41709191 7.727 NM_002192
 INHBA
inhibin, beta A
chr9_+_108726257 5.413 ZNF462
zinc finger protein 462
chr2_+_101874809 5.181 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr14_+_51025604 5.132 NM_001042481
 FRMD6
FERM domain containing 6
chr1_+_168898898 4.793 PRRX1
paired related homeobox 1
chr3_-_64186151 4.759 NM_198859
 PRICKLE2
prickle homolog 2 (Drosophila)
chr7_-_27133163 4.564 NM_153631
 HOXA3
homeobox A3
chr8_-_122722674 4.549 NM_005328
 HAS2
hyaluronan synthase 2
chr7_-_27171648 4.461 HOXA9
homeobox A9
chr2_+_101874765 4.367 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr7_-_13992351 4.354 NM_001163150
NM_001163151
NM_001163152
 ETV1


ets variant 1


chr7_-_27171673 4.313 NM_152739
 HOXA9
homeobox A9
chr3_+_161040343 4.209 NM_001197109
 SCHIP1
schwannomin interacting protein 1
chr12_-_16652202 4.207 NM_001001395
 LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_+_161040439 4.133 SCHIP1
schwannomin interacting protein 1
chr3_-_188935363 4.111 NM_001134738
 BCL6
B-cell CLL/lymphoma 6
chr2_-_160764819 3.922 NM_000888
 ITGB6
integrin, beta 6
chr11_+_101488380 3.918 NM_001195045
 YAP1
Yes-associated protein 1
chr10_+_69539255 3.850 NM_032578
 MYPN
myopalladin

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 165 entries
enrichment   p-value GO term description
3.28 2.01e-03 GO:0007602 phototransduction
3.18 1.31e-11 GO:0048706 embryonic skeletal system development
3.12 2.15e-02 GO:0060688 regulation of morphogenesis of a branching structure
3.11 2.55e-07 GO:0048704 embryonic skeletal system morphogenesis
3.05 4.44e-03 GO:0051153 regulation of striated muscle cell differentiation
2.95 6.54e-05 GO:0001764 neuron migration
2.95 4.72e-03 GO:0009583 detection of light stimulus
2.90 4.13e-02 GO:0050777 negative regulation of immune response
2.79 1.64e-03 GO:0001649 osteoblast differentiation
2.67 7.10e-12 GO:0007156 homophilic cell adhesion
2.61 3.47e-02 GO:0048663 neuron fate commitment
2.54 3.42e-03 GO:0009582 detection of abiotic stimulus
2.50 3.37e-04 GO:0022612 gland morphogenesis
2.47 4.63e-03 GO:0007519 skeletal muscle tissue development
2.46 4.28e-02 GO:0070848 response to growth factor stimulus
2.41 6.63e-04 GO:0021953 central nervous system neuron differentiation
2.40 6.02e-03 GO:0060538 skeletal muscle organ development
2.38 3.50e-09 GO:0048562 embryonic organ morphogenesis
2.35 1.47e-02 GO:0051147 regulation of muscle cell differentiation
2.31 1.33e-07 GO:0045165 cell fate commitment

Gene overrepresentation in compartment category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
2.73 9.12e-03 GO:0005581 collagen
2.50 6.45e-03 GO:0034774 secretory granule lumen
2.44 1.64e-02 GO:0031093 platelet alpha granule lumen
2.42 8.48e-03 GO:0031983 vesicle lumen
2.40 1.43e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.27 4.33e-06 GO:0044420 extracellular matrix part
2.26 2.15e-02 GO:0031091 platelet alpha granule
2.08 1.77e-13 GO:0005578 proteinaceous extracellular matrix
1.92 7.58e-12 GO:0031012 extracellular matrix
1.88 1.25e-04 GO:0030424 axon
1.88 1.41e-02 GO:0030016 myofibril
1.87 1.17e-02 GO:0043292 contractile fiber
1.70 2.43e-02 GO:0005882 intermediate filament
1.68 9.91e-07 GO:0045202 synapse
1.64 9.69e-06 GO:0043005 neuron projection
1.60 2.00e-02 GO:0016323 basolateral plasma membrane
1.56 7.65e-07 GO:0030054 cell junction
1.56 7.60e-03 GO:0044456 synapse part
1.53 1.26e-11 GO:0044421 extracellular region part
1.41 9.28e-05 GO:0005615 extracellular space

Gene overrepresentation in function category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
2.36 3.73e-02 GO:0003707 steroid hormone receptor activity
2.33 3.20e-02 GO:0004879 ligand-dependent nuclear receptor activity
2.05 4.27e-02 GO:0005201 extracellular matrix structural constituent
1.92 3.07e-04 GO:0008083 growth factor activity
1.89 8.88e-03 GO:0060090 binding, bridging
1.84 4.90e-02 GO:0030674 protein binding, bridging
1.81 5.21e-03 GO:0001871 pattern binding
1.81 5.21e-03 GO:0030247 polysaccharide binding
1.81 1.18e-02 GO:0005539 glycosaminoglycan binding
1.76 3.21e-15 GO:0043565 sequence-specific DNA binding
1.73 3.11e-13 GO:0005509 calcium ion binding
1.61 1.73e-14 GO:0001071 nucleic acid binding transcription factor activity
1.61 1.73e-14 GO:0003700 sequence-specific DNA binding transcription factor activity
1.56 6.09e-03 GO:0003779 actin binding
1.51 3.75e-10 GO:0030528 transcription regulator activity
1.45 4.73e-04 GO:0005198 structural molecule activity
1.39 1.45e-05 GO:0005102 receptor binding
1.28 2.43e-03 GO:0004888 transmembrane receptor activity
1.24 3.81e-03 GO:0004872 receptor activity
1.23 4.74e-04 GO:0004871 signal transducer activity